Wang Z, Yu J. Efficacy evaluation of thickened condom in the treatment of premature ejaculation. Emerging and investigational drugs for premature ejaculation. Choosing a selection results in a full page refresh.

A Guide to Prescription Delay Pills

Jenkins LC, Gonzalez J, Tal R, Guhring P, Parker M, Mulhall JP. Compliance With Fluoxetine Use in Men With Primary Premature Ejaculation. Efficacy of dapoxetine in the treatment of premature ejaculation. Published 2011 Aug 2. doi:10.4137/CMRH.S7337.

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Safety and efficacy of tramadol hydrochloride on treatment of premature ejaculation. Hatzimouratidis K. Sildenafil in the treatment of erectile dysfunction: an overview of the clinical evidence. Short- and long-term follow-up results of daily 5-mg tadalafil as a treatment for erectile dysfunction and premature ejaculation. Published 2022 Jan 23. We provide men’s health care in one convenient clinic. To learn more about our services, call 310-794-7700.

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It can be either primary, meaning the man has always had the problem, or secondary, meaning the man has acquired the condition later in life. Premature ejaculation has various timing definitions ranging from ejaculating within one minute of penetration to ejaculating prior to a man's gel erectile dysfunction partner achieving orgasm. Essentially, a man or a couple can suffer from rapid ejaculation if one or both is unhappy with how rapidly the man ejaculates. For some couples, RE can occur 30 seconds into vaginal penetration. For others, RE may extend out to five or ten minutes. As long as one of the partners is dissatisfied, RE is a problem. A man doesn’t have much control over how quickly he ejaculates. Ejaculation is mostly an event of the autonomic nervous system, the part of our nervous system we can’t fully control. Heartbeat, digestion, sweating are all examples of neurologic processes our autonomic nervous system controls. Therefore, when a man gets a signal to ejaculate, the point of no return, he’s going to go. The most sensitive part of the penis is the area around the frenulum, the skin flap on the underside of the penis just below the urethral meatus (where he urinates). There is a spinal cord pathway that connects there and rapidly sends signals to the ejaculation center of the spinal cord. Serotonin, dopamine, prolactin, testosterone and oxytocin are all hormones that play a role in ejaculation. This is a very troubling condition for men as it compromises their sexual satisfaction and inhibits them in relationships. Some recent studies shed light on PE and RE but the exact causes are still not known. Psychological: Classic literature on RE suggests it is a trained sexual response fostered by men secretively masturbating as adolescents and trained to finish quickly. This behavior was then reinforced with early partner encounters where young couples engage in clandestine sexual activity in parents’ basements or car back seats. There is no proof that this is a real thing, however, and physicians suggesting this as a cause of RE reinforces guilt associations with sexuality.

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Published 2023 Aug 10. doi:10.1371/journal.pone.0283091. Efficacy of Sphincter Control Training (SCT) in the treatment of premature ejaculation, a new cognitive behavioral approach: A parallel-group randomized, controlled trial. Published 2019 Feb 26. doi:10.1371/journal.pone.0212274. Neurobiological: The neurotransmitter serotonin (5HT) plays a central role in the ejaculatory response.

What are Premature Ejaculation Pills?

Gillman N, Gillman M. Premature Ejaculation: Aetiology and Treatment Strategies. Published 2019 Oct 25. doi:10.3390/medsci7110102. Behavioral Therapies for Management of Premature Ejaculation: A Systematic Review. Low levels of serotonin in specific areas of the brain may lead premature ejaculation. Studies have shown that increases in serotonin levels can help delay ejaculation in some men. This provides the rationale for treating RE with anti-depressants in the selective serotonin reuptake inhibitor (SSRI) class. Penile Sensitivity: The ejaculatory spinal cord pathway is located at the ventral tip of the corona (if you’re standing up and looking down at your penis, the ventral side is on the bottom. The corona is the mushroom head of your penis.) If a man has increased sensitivity at that point, he will likely ejaculate too fast. Applying topical numbing agents, usually containing lidocaine, is an effective way to reduce penile sensitivity and prolong ejaculation. It is important to wash the penis prior to intercourse, or wear a condom, to avoid desensitizing the partner, however. At UCLA Health—The Men’s Clinic, physicians are trained to treat rapid ejaculation and have a number of methods available.

Medication Name Active Ingredient Usage Frequency Typical Dose Side Effects Prescription Required Cost ($)
Dapoxetine Dapoxetine As needed 30 mg before sex Nausea, dizziness Yes 1.5-2.5
SSRIs (off-label) Sertraline, Paroxetine Daily 50-100 mg daily Fatigue, dry mouth Yes 1-2 per pill
Tramadol (off-label) Tramadol As needed 50 mg Drowsiness, nausea Yes 0.50-0.80 per pill

Treatment for PE and RE centers around behavioral, neurologic and hormonal modifications.

Preparing for your appointment

You can find out more about how we ensure our content is accurate and current by reading our editorial policy. Zhang D, Cheng Y, Wu K, Ma Q, Jiang J, Yan Z. Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis. Published 2019 Jan 3. doi:10.1186/s12894-018-0431-7.

1. Zinc

Arafa M, Shamloul R. A randomized study examining the effect of 3 SSRI on premature ejaculation using a validated questionnaire. Madeo B, Bettica P, Milleri S, Balestrieri A, Granata AR, Carani C, Rochira V. The effects of citalopram and fluoxetine on sexual behavior in healthy men: evidence of delayed ejaculation and unaffected sexual desire. A randomized, placebo-controlled, double-blind, double-dummy, parallel group study. Behavioral Therapy: Some patients respond to techniques such as starting and stopping.

Selective serotonin uptake inhibitors (SSRIs)

doi:10.1080/2090598X.2021.2024695. On-demand Modafinil Improves Ejaculation Time and Patient-reported Outcomes in Men With Lifelong Premature Ejaculation. Comparison of alpha blockers in treatment of premature ejaculation: a pilot clinical trial. [Yimusake Tablet: safe and efficacious for premature ejaculation]. Mark KP, Kerner I.

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Event-level impact of Promescent on quality of sexual experience in men with subjective premature ejaculation. "Randomized, Pacebo-Controlled study To Evaluate The Efficacy, Safety, And Tolerability of Benzocaine Wipes in Subjects With Premature Ejaculation - Journal of Men's Health. Oss.jomh.org, 2019, Accessed on Mar, 27, 2024. Doğan K, Keçe C. Comparison of the results of stop-start technique with stop-start technique and sphincter control training applied in premature ejaculation treatment. This basically involves interrupting intercourse to decrease stimulation to the penis in hopes of cooling the nerves down. Although effective at times, most patients report limited sexual satisfaction with these methods. Topical medications: One of the simplest treatment option is to temporarily desensitize the head of the penis by using a topical anesthetic medications for premature ejaculation. They are effective, easy-to-use, low-cost and have a negligible risk of systemic side effects.

Supplement Name Main Ingredients Claim Typical Dosage Available Forms Price ($)
Semenax L-arginine, Tribulus terrestris Libido boost, delay As directed Capsules 30-60
Premature Eject Maca root, Ginseng Improve control 2 capsules/day Capsules 20-40
Max Performer Fenugreek, Zinc Longer endurance Once daily Tablets 25-50
ProLonger L-Tyrosine, Horny Goat Weed Delay climax 1-2 capsules Capsules 15-35

Topical numbing sprays and creams are available with either a prescription or over the counter. They all work by gently numbing the sensitive areas of the penis so the nerves don’t fire so fast and the man can prolong intercourse. The agent must be washed off prior to intercourse or a condom must be worn to make sure the partner is not also desensitized.

  • Topical anesthetic creams and sprays are alternative options.
  • Lifestyle modifications, like reducing stress, are helpful adjuncts.
  • Natural pills should be scrutinized for scientific validation.
  • Contraceptive pills do not treat PE but are often confused with treatments.
  • Medications may have different durations of action depending on formulation.

One option for patients is a new product, Promescent®, from Absorption Pharmaceuticals, which provides improved ejaculatory latency (the time from penetration to ejaculation) with minimal loss of sexual sensation. Oral medications: Some men respond well to low doses of the antidepressants known as selective serotonin reuptake inhibitors (SSRIs), that block serotonin, one of the hormones important in ejaculation. These are prescribed off-label, with some side effects. These pills have been around for over 20 years, are relatively safe, but are not FDA approved for PE / RE. It is therefore up to the patient and his doctor to make the call to use this class of drugs off label.

  • Prescription pills must be taken under medical supervision.
  • Natural remedies often include ingredients like ginseng or yohimbine.
  • Over-the-counter delay sprays can also help.
  • Consistent use of certain medications may reduce PE frequency.
  • Psychological counseling can be effective for performance anxiety.

Don’t be afraid to seek treatment for premature or rapid ejaculation. It is a very common condition, and one of the most common sexual dysfunctions. Your UCLA Men’s Clinic provider will be understanding and likely have an effective treatment that will please you and your partner. Board-certified urologists staff The Men’s Clinic at UCLA and you can be assured you are getting an experienced physician performing your evaluation and procedure in a relaxed and comfortable environment. For more information and to schedule an appointment, please call the UCLA Urology Appointment line at 310-794-7700. Combination therapy of sildenafil and clomipramine significantly improves ejaculatory latency time and patient-reported outcomes in men with PE compared to monotherapies.

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These include SSRIs, Pain relievers, ED pills, Modanafil, Alpha Blockers, and Chinese herbal medicine. Most of these medications have been found to cause only mild side effects if any at all. Nonetheless, patients may find that drugs alone won’t help. In this case, behavioral techniques, a combination of behavioral techniques and drugs, or other alternative treatments might be more helpful Patients should consult with a doctor to determine their best option before starting a treatment plan for premature ejaculation. Dr.

Tadalafil (Cialis)

Gary Bellman is a board certified urologist specializing in Men's Health. He is the owner and founder of the Southern California Urology Institute and has 30 years of experience taking care of men's health issues. Absorption Pharmaceuticals LLC (Promescent) has strict informational citing guidelines and relies on peer-reviewed studies, academic or research institutions, medical associations, and medical experts. We attempt to use primary sources and refrain from using tertiary references and only citing trustworthy sources. Each article is reviewed, written, and updated by Medical Professionals or authoritative Experts in a specific, related field of practice. The phase 3 trial involved 795 men across 24 sites in Korea, showing greater efficacy of combination therapy in improving IELT, PEP, and PGIC scores.